Monitoring Contamination in Critical Environments

Maintaining aseptic conditions in pharmacies, labs, and clean rooms requires more than just airflow control—environmental monitoring through air and surface sampling is essential. At HPI, we provide volatile and non-volatile sampling services designed to detect chemical and microbial contamination on surfaces and in ambient air.

🧪 What Is Volatile vs. Non-Volatile Sampling?

Type Target Contaminants Common Uses

Volatile Sampling Chemical vapors, solvents, VOCs Hazardous drug compounding, chemical labs

Non-Volatile Sampling Particulate matter, microorganisms (bacteria, fungi) Clean rooms, sterile compounding, biotech

Volatile sampling captures airborne chemical hazards, while non-volatile sampling focuses on physical or biological contaminants—often via surface swabs, agar plates, or air samplers.

📋 Surface Sampling Services

Surface sampling is crucial in identifying residues that could impact product sterility or safety.

Our Services Include:

• Viable Surface Sampling
  Using contact plates or swabs for microbial load detection

• Non-Viable Surface Residue Sampling
  For particulate matter or chemical residues

• Wipe Sampling for Hazardous Drug Residue
  Per USP <800> and NIOSH recommendations

All results are analyzed by accredited laboratories, and documentation is provided for audits and compliance.

🌫️ Air Sampling Services

Monitoring air quality is key for contamination control and USP compliance.

We Offer:

• Non-Viable Air Sampling (Particle Counts)
  → Measured in particles/ft³ or m³ using laser particle counters

• Viable Air Sampling (Microbial)
  → Impaction samplers with TSA or SDA media

• Volatile Organic Compound (VOC) Sampling
  → Sorbent tubes or real-time sensors for chemical vapors

Performed in ISO 5, 7, and 8 areas per USP <797>/<800>, ISO 14698, and FDA guidelines.

🧼 Where Sampling Is Performed

• Primary Engineering Controls (PECs)
  Biosafety cabinets, isolators, laminar hoods

• Buffer and Anterooms
  For clean room classification and monitoring

• Hazardous Drug Handling Areas
  Especially for USP <800> compliance

• Sterile Compounding Spaces

We help you establish a monitoring program or conduct periodic validations.

📊 Reporting & Compliance

• Comprehensive lab reports

• Chain-of-custody documentation

• Trending analysis over time

• Pass/fail summary by sampling site

📅 Schedule Environmental Sampling Today

Whether you're due for a routine audit, establishing a baseline, or investigating contamination, HPI is ready to help.